DeLisle plays a leading role in at least six current animated series. Harp has called DeLisle "golden-voiced" and recognized her for her roles in The Fairly Oddparents as well as Clifford the Big Red Dog and its prequel, Clifford's Puppy Days. She is the most recent actress to voice Daphne Blake in Scooby-Doo! Mystery Incorporated. In addition to her numerous English-speaking roles, she also speaks Japanese as the character Yumi on Hi Hi Puffy AmiYumi. DeLisle has had voice acting roles in many computer and video games, such as Escape from Monkey Island, Baldur's Gate II: Shadows of Amn, Tomb Raider: Anniversary, Tomb Raider: Underworld and several Star Wars games.
As a television voice actress, she portrays the Dark Jedi Asajj Ventress in 5 episodes of Star Wars: Clone Wars and reprises her role as Ventress in a bonus level in the Force Duel mode of the PSP version of the video game Star Wars: The Force Unleashed. She also portrays Frankie, Duchess, and Goo on Foster's Home for Imaginary Friends, Azula on Avatar: The Last Airbender, Riley Daring on The Replacements, several voice roles (though mainly Mandy) on The Grim Adventures of Billy & Mandy, Therese and Jeanette (Tourette) Voerman in the White Wolf RPG PC game Vampire: The Masquerade – Bloodlines, Frida Suárez in El Tigre: The Adventures of Manny Rivera, Sam Manson in Danny Phantom, as well as Vicky and her sister Tootie in The Fairly OddParents in Xiaolin Showdown as Kimiko Tohomiko and also in W.I.T.C.H as Miranda. She currently voices agent Kitty Katswell in the animated show T.U.F.F. Puppy on Nickelodeon. DeLisle also voiced Nancy Suzy Fish from the second season on SpongeBob SquarePants.
She can also be heard on each of Frederator Studios' vanity cards, as she shouts "Frederator!". She also had a role in Transformers: Revenge of the Fallen as the Arcee triplets. Also, she had a role in the critical acclaimed game Metal Gear Solid: Peace Walker as Amanda Valenciano Libre, a female character that supports Big Boss. Delisle also stars as "Tabby" in the internet animation series It's Fred!.
See her full credits list here.